The chemistry of thujone. XIX. Acid-promoted ring cleavage of thujone-derived cyclopropylcarbinols

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Ring Cleavage of Some Bicylic Compounds Derived from 1,2,4-Triazine

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ring cleavage of some bicylic compounds derived from 1,2,4-triazine

ring cleavage occurred when 1,2,4-triazino-1,2,4-triazines (3), (4) and (5) were treated with concentrated hydrochloric acid to yield n-substituted triazines (7) and (8). these confirm the given configuration assigned to the isomeric triazinotriazines. 6-methyl-2-phenyl-7h-oxazolo [3,2-b][1,2,4]-triazin-7-one (9) underwent ring cleavage on treatment with sodium alkoxide to afford 3-alkoxy-1,2,4...

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α-Thujone (the active component of absinthe): γ-Aminobutyric acid type A receptor modulation and metabolic detoxification

α-Thujone is the toxic agent in absinthe, a liqueur popular in the 19th and early 20th centuries that has adverse health effects. It is also the active ingredient of wormwood oil and some other herbal medicines and is reported to have antinociceptive, insecticidal, and anthelmintic activity. This study elucidates the mechanism of α-thujone neurotoxicity and identifies its major metabolites and ...

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ژورنال

عنوان ژورنال: Canadian Journal of Chemistry

سال: 1996

ISSN: 0008-4042,1480-3291

DOI: 10.1139/v96-194